• Change in condition being treated. Is it better, worse, or about the same?
• If you are a female of childbearing age, take a pregnancy test before starting this medicine.
• If you are a female of childbearing age, take a monthly pregnancy test.
• Check blood work (liver function, hemoglobin, hematocrit). Talk with healthcare provider.
• Follow up with healthcare provider.
• Store at room temperature.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2005-04-07 16:22:37.0
Modified: 2010-03-09 08:28:07.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Avoid grapefruit and grapefruit juice.
• Avoid or limit alcohol intake (includes wine, beer, and liquor) to less than 3 drinks a day. Drinking too much alcohol may increase the risk of liver disease.
• Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.
• Headache.
• Lung infection.
• Flushing.
• Muscle pain.
• Swelling.
• Male infertility.
• Anemia can rarely occur.
• Liver damage can rarely occur.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Difficulty breathing.
• Severe belly pain.
• Severe nausea or vomiting.
• Not able to eat.
• Dark urine or yellow skin or eyes.
• Feeling extremely tired or weak.
• Significant weight gain.
• For females, if you become pregnant while taking this medicine.
• Any rash.
• No improvement in condition or feeling worse.
• This medicine may cause severe liver damage.
• Do not take this medicine if you are pregnant.
• You cannot obtain this medicine from your pharmacy. It is available only through the company which makes it.
• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• Please read the medication guide.
• If you have an allergy to bosentan or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have liver disease.
• If you are pregnant or may be pregnant.
• If you are breast-feeding.
• Bosentan blocks endothelin, a chemical in the blood that causes blood vessels to narrow.
• To gain the most benefit, do not miss doses.
• Take this medicine with or without food. Take with food if it causes an upset stomach.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
