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Brimonidine and Timolol Contributions by FoundHealth

Article Revisions

(bri MOE ni deen & TIM oh lol)

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Combigan®

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Combigan®

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Alpha2 Agonist, Ophthalmic; Beta Blocker, Nonselective; Ophthalmic Agent, Antiglaucoma

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• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

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• If you have an allergy to brimonidine, timolol, or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Asthma, severely weakened heart, slow heartbeat without a working pacemaker, or wheezing.

• If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.

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• Brimonidine and timolol lower pressure in the eye.

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• For the eye only.

• Take out contact lenses before using medicine. Lenses can be replaced 15 minutes after medicine is given. Do not put contacts back in if eyes are irritated or infected.

• Do not touch the container tip to the eye, lid, or other skin.

• Tilt head back and drop medicine into eye.

• After using medicine, keep your eyes closed. Apply pressure to the inside corner of the eye. Do this for 3-5 minutes. This keeps the medicine in your eye.

• Separate each eye medicine by 10 minutes.

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• Instill a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not instill a double dose or extra doses.

• Do not change dose or stop medicine. Talk with healthcare provider.

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• Change in condition being treated. Is it better, worse, or about the same?

• Have eye pressure checked regularly. Talk with healthcare provider.

• Check blood pressure and heart rate regularly if you have heart disease.

• Follow up with healthcare provider.

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• Store at room temperature.

• Protect from light.

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Created: 2007-07-11 14:06:03.0

Modified: 2010-03-23 10:24:54.0

Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.

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• This medicine is used to treat glaucoma.

• This medicine is used to decrease high eye pressure.

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• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

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What are the precautions when taking this medicine?

• If you are diabetic and have low blood sugar, talk with healthcare provider. This medicine hides the signs of low blood sugar except sweating.

• If you have lung disease, talk with healthcare provider.

• If you have a weakened heart, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Tell healthcare provider if you are pregnant or plan on getting pregnant.

• Tell healthcare provider if you are breast-feeding.

What are some possible side effects of this medicine?

• Eye irritation.

• Blurred vision. Use caution when driving or doing other tasks that require you to have clear vision.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Severe dizziness or passing out.

• Difficulty breathing.

• Sudden change in vision, eye pain, or irritation.

• Any rash.

• No improvement in condition or feeling worse.

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