• The desire to harm yourself is a serious symptom of depression. It may last until your depression is completely treated. If you are planning on harming yourself, call the emergency department right away.
• There is a risk of serotonin syndrome when using a migraine medicine with this medicine. The syndrome is caused by too much serotonin in the body. Signs include: agitation, changes in blood pressure, diarrhea, fast heartbeat, hallucinations, nausea and vomiting, significant change in balance, and significant change in thinking clearly and logically. Talk with healthcare provider.
• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• Please read the medication guide.
• If you have an allergy to duloxetine or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.
• If you have glaucoma.
• Duloxetine increases chemicals in the brain.
• In depression, sleep and appetite may improve quickly. Other depressive symptoms may take up to 4-6 weeks to improve.
• To gain the most benefit, do not miss doses.
• Take this medicine with food to prevent stomach upset.
• Swallow whole. Do not chew, break, or crush.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Change in condition being treated. Is it better, worse, or about the same?
• Have eye pressure checked regularly. Talk with healthcare provider.
• Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.
• Follow up with healthcare provider.
• Store at room temperature.
• Protect from light.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2006-10-13 12:09:29.0
Modified: 2010-03-19 13:40:56.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• This medicine is used to treat depression.
• This medicine is used to relieve painful nerve diseases and diabetic nerve disorders.
• This medicine is used to relieve chronic pain conditions.
• This medicine is used to treat anxiety.
• If you have been taking this medicine for several weeks, talk with healthcare provider before stopping. You may want to gradually withdraw this medicine.
• If you have bleeding problems, talk with healthcare provider.
• If you have diabetes, talk with healthcare provider.
• If you have high blood pressure, talk with healthcare provider.
• If you have kidney disease, talk with healthcare provider.
• If you have liver disease, talk with healthcare provider.
• If you have seizures, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Talk with healthcare provider before using aspirin, aspirin-containing products, other pain medicines, blood thinners, garlic, ginseng, ginkgo, or vitamin E.
• You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.
• Avoid alcohol (includes wine, beer, and liquor) or other medicines and natural products that slow your actions and reactions.
• Tell healthcare provider if you are pregnant or plan on getting pregnant.
• Tell healthcare provider if you are breast-feeding.
• Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
• Nervous and excitable.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
• Diarrhea.
• Headache.
• Dry mouth. Frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Change in sexual ability or desire. This is usually reversible.
• Inability to sleep.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• If you are planning to harm yourself or the desire to harm yourself increases.
• Significant change in thinking clearly and logically.
• Significant change in balance.
• Agitation, twitching, sweating, or muscle stiffness.
• Severe nausea or vomiting.
• Feeling extremely tired or weak.
• Fast heartbeat.
• Unusual bruising or bleeding.
• Dark urine or yellow skin or eyes.
• Not able to eat.
• Feeling extremely tired or weak.
• Any rash.
• No improvement in condition or feeling worse.
