• Estrogens, when used in females after menopause, may increase the risk of uterine cancer. Progestins may decrease this risk. A warning sign for cancer of the uterus is unusual vaginal bleeding. Report any unusual vaginal bleeding to healthcare provider.
• Do not take estrogens to prevent heart disease or dementia. Using estrogens may increase your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• If you have an allergy to estradiol or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have any of the following conditions: Blood clots, breast cancer, liver disease, recent heart attack, recent stroke, tumor where estrogen makes it grow, or unexplained vaginal bleeding.
Vaginal cream/tablet:
• Use cream or tablet vaginally.
• Wash your hands and applicator after use.
Vaginal ring:
• Insert vaginally and leave in place for 90 days.
• Follow directions given by healthcare provider or read the package insert.
• Remove ring on the beginning of the thirteenth week.
• Insert a new ring.
• To insert, wash your hands and remove ring from protective pouch.
• Press sides of ring together between thumb and index finger and insert folded ring into vagina.
• Perfect placement is not required for ring to be effective. Ring should be comfortable.
• To remove, hook index finger around rim or hold rim between index finger and middle finger and pull out.
• Do not throw the vaginal ring in the toilet.
• Use a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not use a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Change in condition being treated. Is it better, worse, or about the same?
• Periodic breast (monthly self-exam) and yearly gynecologic exams are important.
• Follow up with healthcare provider yearly.
Created: 2010-01-11 11:16:56.0
Modified: 2010-07-20 13:38:41.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• Read the package insert for more details.
• There may be a higher risk of endometrial or breast cancer.
• If you have any circulation problems, talk with healthcare provider.
• If you have heart disease, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Avoid cigarette smoking. Persons older than 35 years of age and/or smoking more than 15 cigarettes per day are at an increased risk for heart disease.
• Limit alcohol intake (includes wine, beer, and liquor).
• Vaginal irritation.
• For females, vaginal yeast infection. Report itching or discharge.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Swelling or pain of leg or arm.
• Severe vaginal irritation.
• A lump in the breast or breast tenderness.
• Any rash.
• No improvement in condition or feeling worse.
