• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• If you have an allergy to ezetimibe, simvastatin, or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have active liver disease or an increase in liver enzymes.
• If you are pregnant or may be pregnant.
• If you are breast-feeding.
• Simvastatin reduces cholesterol production.
• Ezetimibe reduces the amount of cholesterol absorbed.
• Take this medicine in the evening.
• Take this medicine with or without food. Take with food if it causes an upset stomach.
• Follow diet plan and exercise program as recommended by healthcare provider.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Change in condition being treated. Is it better, worse, or about the same?
• Check blood work (cholesterol panel, liver function). Talk with healthcare provider.
• Follow up with healthcare provider.
• Store at room temperature.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2006-10-13 12:31:22.0
Modified: 2010-06-22 14:23:37.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• This medicine is used to slow the progress of heart disease.
• This medicine is used to lower cholesterol and other harmful types of cholesterol in the body. Good cholesterol (HDL) levels increase.
• This medicine is used to decrease triglycerides.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• If you have kidney disease, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Do not take colestipol or cholestyramine within 4 hours of this medicine.
• Avoid or limit alcohol intake (includes wine, beer, and liquor) to less than 3 drinks a day. Drinking too much alcohol may increase the risk of liver disease.
• Avoid grapefruit and grapefruit juice.
• You can get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen; wear protective clothing and eyewear.
• Use birth control that you can trust to prevent pregnancy while taking this medicine.
• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
• Headache.
• Belly pain.
• Feeling tired or weak.
• Diarrhea.
• Muscle weakness.
• Joint pain.
• Runny nose.
• Sore throat.
• Liver damage can rarely occur.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Severe muscle pain or weakness.
• Flu-like symptoms.
• Unusual bruising or bleeding.
• Not able to eat.
• Dark urine or yellow skin or eyes.
• Feeling extremely tired or weak.
• Any rash.
• No improvement in condition or feeling worse.
