• Spironolactone can cause tumors in animals. These were long-term studies using larger doses than would be used in humans.
• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• If you have an allergy to hydrochlorothiazide, spironolactone, or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have a sulfonamide ("sulfa") allergy, talk with healthcare provider.
• If you have any of the following conditions: High potassium levels or kidney disease.
• Hydrochlorothiazide (HCTZ) lowers blood pressure and gets rid of extra salt and water in the body through the kidneys.
• Spironolactone prevents potassium loss.
• Take this medicine early in the day to avoid sleep problems.
• Take this medicine with food.
• Follow diet plan and exercise program as recommended by healthcare provider.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Store at room temperature.
• Protect from light.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2006-10-13 13:03:15.0
Modified: 2010-04-27 14:40:43.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• This medicine is used to treat high blood pressure.
• This medicine is used to get rid of extra fluid.
• Change in condition being treated. Is it better, worse, or about the same?
• If you are diabetic, you will need to monitor blood sugars closely.
• Check blood pressure and heart rate regularly. Talk with healthcare provider.
• Check blood work (potassium). Talk with healthcare provider.
• Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• Wear disease medical alert identification.
• If you have diabetes, talk with healthcare provider. This medicine can increase blood sugar.
• If you have kidney disease, talk with healthcare provider.
• If you have liver disease, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• If you are taking potassium-containing salt substitutes, potassium-sparing diuretics, or potassium supplements, talk with healthcare provider.
• If you are taking this medicine and have high blood pressure, talk with healthcare provider before using over-the-counter products that may increase blood pressure. These include cough or cold remedies, diet pills, stimulants, ibuprofen or like products, and certain natural products or supplements.
• Avoid alcohol (includes wine, beer, and liquor).
• You can get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen; wear protective clothing and eyewear.
• Watch for gout attacks.
• Tell dentists, surgeons, and other healthcare providers that you use this medicine.
• Tell healthcare provider if you are pregnant or plan on getting pregnant.
• Tell healthcare provider if you are breast-feeding.
• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Dry mouth. Frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• For females, breast tenderness, deepening of voice, or increased hair growth.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Excessive perspiration, dehydration, vomiting, or diarrhea. May lead to low blood pressure.
• Severe dizziness or passing out.
• Severe nausea or vomiting.
• Unable to pass urine.
• For males, enlarged breasts.
• For females, menstrual changes. These include lots of bleeding, spotting, or bleeding between cycles.
• Any rash.
• No improvement in condition or feeling worse.
