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Methylprednisolone Contributions by FoundHealth

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Side effects

Steroids can induce hypersensitivity reactions. Get emergency care if you notice:

  • hives
  • difficulty breathing
  • swelling of your face, lips, tongue, or throat.

Contact your doctor immediately if you have any of these serious side effects:

  • vision changes
  • unusual thoughts or behavior
  • seizure (convulsions)
  • signs of bleeding such as bloody or tarry stools, coughing up blood
  • severe pain in your upper stomach
  • fast heart rate
  • signs and symptoms of low potassium levels: confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness
  • high blood pressure
  • chest pain
  • shortness of breath
  • irregular heart beats

Below are considered as less serious side effects that may occur with steroid use

  • sleep problems (insomnia), mood changes;
  • skin changes: dryness, skin thinning, bruising or discoloration, acne
  • delayed wound healing
  • headache, dizziness
  • stomach pain, nausea, bloating
  • changes in the shape or location of body fat

Warnings

  • Methylprednisolone can cause you to have unusual results with some medical tests. You should always tell any doctor who treats you that you are using methylprednisolone. * Abrupt discontinuation of methylprednisolone therapy could produce unpleasant withdrawal symptoms. Ask your doctor about how you could avoid possible withdrawal symptoms.
  • Wear a medical alert bracelet or an ID card stating that your on steroid therapy so that in case of emergency, anyone attending to you would know that you are taking steroids.
  • You should tell your doctor if you are taking prescription and over-the-counter medications you use including vitamins, minerals, and supplements.

Drug interactions

Below are some of the medicines that are known to interact with steroids:

  • aspirin
  • diuretics
  • blood thinners
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • diabetes medications
  • ketoconazole (Nizoral);
  • rifampin (Rifadin, Rifater, Rifamate, Rimactane); or
  • seizure medications such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

What are the precautions when taking this medicine?

• If you have been taking this medicine for several weeks, talk with healthcare provider before stopping. You may want to gradually withdraw this medicine.

• Wear disease medical alert identification.

• Talk with healthcare provider before receiving any vaccinations. Use with this medicine may either increase the risk of serious infection or make the vaccination less effective.

• Do not run out of this medicine.

• Avoid exposure to chickenpox and measles.

• Do not take antacids within 2 hours of this medicine.

• If you have diabetes, talk with healthcare provider. This medicine can increase blood sugar.

• If you have glaucoma or cataracts, talk with healthcare provider.

• If you have high blood pressure, talk with healthcare provider.

• If you have osteoporosis, talk with healthcare provider.

• If you have stomach ulcers, talk with healthcare provider.

• If you have tuberculosis, talk with healthcare provider.

• If you have a weakened heart, talk with healthcare provider.

• Tell dentists, surgeons, and other healthcare providers that you use this medicine.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Avoid alcohol (includes wine, beer, and liquor).

• Tell healthcare provider if you are pregnant or plan on getting pregnant.

• Tell healthcare provider if you are breast-feeding.

What are some possible side effects of this medicine?

• High blood sugar. Usually reverses when stopped.

• Risk of infection. Avoid people with infections, colds, or flu.

• Belly pain.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Weight gain.

• Mood changes.

• Change in body fat distribution.

• Weakened bones with long-term use.

• Muscle weakness.

• Skin changes (acne, stretch marks, slow healing, hair growth).

• Cataracts or glaucoma with long-term use.

• For females, vaginal yeast infection. Report itching or discharge.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.

• Feeling extremely tired, weak, or irritable; trembling; having a fast heartbeat, confusion, sweating, or dizziness if you missed a dose or recently stopped this medicine.

• Difficulty breathing.

• Significant weight gain.

• Severe nausea or vomiting.

• Sudden change in vision.

• If exposure to chickenpox has occurred and you have not had chickenpox or been vaccinated against it.

• Any rash.

• No improvement in condition or feeling worse.

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(meth il pred NIS oh lone)

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A-Methapred®; Depo-Medrol®; Medrol®; Solu-Medrol®

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Depo-Medrol®; Medrol®; Methylprednisolone Acetate; Solu-Medrol®

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Advantan; Cryosolona; Depo-Medrol; Predlitem; Solu-Medrol

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Corticosteroid, Systemic

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• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

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• If you have an allergy to methylprednisolone or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have a severe infection.

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• Methylprednisolone replaces an important chemical produced in the body.

• It blocks the allergic reaction by minimizing or preventing the body's reaction to the allergen.

• It prevents or reduces irritation and swelling.

• It decreases the body's harmful response to diseases affecting the immune system.

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• To gain the most benefit, do not miss doses.

• Use prescription as directed, even if feeling better.

• Directions may change; read label closely.

• Take this medicine in the morning if taking once a day.

• Take this medicine with food to prevent stomach upset.

• Take calcium and vitamin D as recommended by healthcare provider.

Injection:

This medicine is given as a shot into a muscle or vein.

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• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

• Do not change dose or stop medicine. Talk with healthcare provider.

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• Change in condition being treated. Is it better, worse, or about the same?

• Check blood sugar as directed by healthcare provider.

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• Store at room temperature.

• Protect tablets from moisture. Do not store in a bathroom or kitchen.

• The injection will be given to you in a healthcare setting. You will not store it at home.

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Edited Methylprednisolone Overview: 14 years ago

Created: 2006-10-13 14:12:48.0

Modified: 2010-03-25 14:04:54.0

Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.

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• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

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• This medicine is used to relieve allergy symptoms.

• This medicine is used to treat Addison's disease.

• This medicine is used to treat diseases where the anti-inflammatory or immunosuppressant properties are needed.

• This medicine is used to treat a variety of skin rashes.

• This medicine is used to treat spinal cord injuries.

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