• This medicine may cause damage to your heart in certain situations. Talk with healthcare provider. Patients with liver disease need a lower dose. This medicine can have severe effects on the bone marrow. The bone marrow may not be able to produce the cells found in the blood as well as it used to. You will be closely monitored by healthcare provider. The risk of cancer is higher after taking this medicine.
• This medicine may irritate or damage the vein.
• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• This medicine is given as a shot into a vein only.
• If you have an allergy to mitoxantrone or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have any of the following conditions: Bone marrow disease or a severely weakened heart.
• If you have received a full treatment with daunorubicin, doxorubicin, epirubicin, or idarubicin.
• If you have received the maximum lifetime dose already. This may vary, talk with healthcare provider.
• If you are pregnant or may be pregnant.
• If you are breast-feeding.
• Mitoxantrone injures cancer cells causing their death.
• It decreases the body's harmful response to diseases affecting the immune system.
• This medicine will be given to you in a healthcare setting. You will not store it at home.
Created: 2005-04-07 17:00:58.0
Modified: 2010-03-09 08:29:42.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• This medicine is used to treat a variety of cancers.
• This medicine is used to treat leukemia.
• This medicine is used to treat lymphoma.
• This medicine is used to treat multiple sclerosis.
• Change in condition being treated. Is it better, worse, or about the same?
• Heart function tests. Talk with healthcare provider.
• Check blood work regularly. Talk with healthcare provider.
• Check weight weekly. Report a weight loss to healthcare provider.
• Follow up with healthcare provider.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• If you have heart disease, talk with healthcare provider.
• If you have liver disease, talk with healthcare provider.
• If you have had radiation therapy, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Talk with healthcare provider before receiving any vaccinations. Use with this medicine may either increase the risk of serious infection or make the vaccination less effective.
• Tell dentists, surgeons, and other healthcare providers that you use this medicine.
• You may bleed more easily. Be careful. Avoid injury. Use soft toothbrush, electric razor.
• Talk with healthcare provider before using aspirin, aspirin-containing products, other pain medicines, blood thinners, garlic, ginseng, ginkgo, or vitamin E.
• Use birth control that you can trust to prevent pregnancy while taking this medicine.
• Risk of infection. Avoid people with infections, colds, or flu.
• Change in color of body fluids to blue or green.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Diarrhea.
• Constipation.
• Headache.
• Swelling.
• Mouth and lip irritation. Frequent mouth care with a soft toothbrush or cotton swabs and rinsing mouth may help.
• Hair loss. Hair usually grows back when medicine is stopped.
• Feeling tired or weak.
• Anemia, low white blood cell count, and low platelet count.
• For females, no menstrual cycle.
• Heart damage can rarely occur.
• Other forms of cancer can rarely occur later in life.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.
• Difficulty breathing.
• Severe dizziness or passing out.
• Swelling of legs or belly.
• Severe nausea or vomiting.
• Unusual bruising or bleeding.
• Feeling extremely tired or weak.
• Severe skin irritation.
• Any rash.
• No improvement in condition or feeling worse.
