• Patients receiving this medicine should be monitored for misuse, abuse, and addiction.
• Do not take with alcohol or alcohol-containing products. Serious reactions can occur.
• Do not chew, crush, or dissolve capsules. Serious reactions can occur.
• Do not use for immediate pain relief or on an as needed basis.
• Do not take the highest dose (100 mg/4 mg) if you have never taken opioids in the past.
• Please read the medication guide.
• If you have an allergy to morphine, naltrexone, or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have any of the following conditions: Asthma, intestinal blockage, or lung disease.
• If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.
• If you are breast-feeding.
• Morphine sulfate binds to brain receptors, relieving pain. It decreases the feeling of pain and a person's response to pain.
• Naltrexone prevents drug-seeking behavior.
• Take this medicine with or without food, but be consistent. Always take with food or always take on an empty stomach.
• Swallow whole. Do not chew, break, or dissolve.
• Do not use for immediate pain relief or on an as needed basis.
• You may sprinkle contents of capsule on applesauce. Do not chew.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Change in condition being treated. Is it better, worse, or about the same?
• Keep a diary of pain control.
• Bowel movements.
• Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.
• Store at room temperature.
• Protect from light.
• Protect from moisture. Do not store in a bathroom or kitchen.
• Throw away any unused medicine by flushing down toilet or sink.
Created: 2009-10-01 08:52:14.0
Modified: 2010-03-22 10:54:01.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• This medicine may be habit-forming with long-term use.
• If you have liver disease, talk with healthcare provider.
• If you have kidney disease, talk with healthcare provider.
• If you have seizures, talk with healthcare provider.
• If you have thyroid disease, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.
• Avoid alcohol (includes wine, beer, and liquor) or other medicines and natural products that slow your actions and reactions.
• Tell healthcare provider if you are pregnant or plan on getting pregnant.
• Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
• Dry mouth. Frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Severe dizziness or passing out.
• Difficulty breathing.
• Significant change in thinking clearly and logically.
• Poor pain control.
• Severe nausea or vomiting.
• Severe constipation.
• Feeling extremely tired or weak.
• Any rash.
• No improvement in condition or feeling worse.
