• This medicine may increase the risk of heart attack, stroke, and high blood pressure. This has been observed with long-term use or at critical times (right after heart surgery). Use caution if you have risk factors for heart disease (high blood pressure, high cholesterol, overweight, diabetes, cigarette smoking, male older than 40 years of age, other family members with early heart disease, postmenopausal female).
• Do not use this medicine right before or after heart bypass surgery.
• This medicine may increase the risk of ulcer or bleeding from the stomach or intestines. Talk with healthcare provider.
• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• Please read the medication guide.
• If you have an allergy to oxycodone, ibuprofen, or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have any of the following conditions: Asthma, intestinal blockage, or lung disease.
• If you are more than 24 weeks pregnant.
• If you are breast-feeding.
• Oxycodone binds to brain receptors, relieving pain. It decreases the feeling of pain and a person's response to pain.
• Ibuprofen blocks production and release of chemicals that cause pain and inflammation.
• Take this medicine with or without food. Take with food if it causes an upset stomach.
• Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by healthcare provider.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Many times this medicine is taken on an as needed basis.
• Change in condition being treated. Is it better, worse, or about the same?
• Keep a diary of pain control.
• Bowel movements.
• Store at room temperature.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2006-10-13 14:48:29.0
Modified: 2010-03-22 14:15:22.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• This medicine may be habit-forming with long-term use.
• If you are 65 or older, use this medicine with caution. You could have more side effects.
• If you have kidney disease, talk with healthcare provider.
• If you have had an ulcer or bleeding from your stomach or intestines, talk with healthcare provider.
• If you have a weakened heart, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Talk with healthcare provider before using other: aspirin, aspirin-containing products, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain medicines, or vitamin E.
• Do not take colestipol or cholestyramine within 2 hours of this medicine.
• Tell dentists, surgeons, and other healthcare providers that you use this medicine.
• You may bleed more easily. Be careful. Avoid injury. Use soft toothbrush, electric razor.
• You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.
• Avoid alcohol (includes wine, beer, and liquor) or other medicines and natural products that slow your actions and reactions.
• Tell healthcare provider if you are pregnant or plan on getting pregnant.
• Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
• Headache.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Severe dizziness or passing out.
• Chest pain or pressure.
• Change in strength on one side greater than the other, difficulty speaking or thinking, change in balance, or blurred vision.
• Difficulty breathing.
• Significant change in thinking clearly and logically.
• Poor pain control.
• Severe nausea or vomiting.
• Severe belly pain.
• Severe swelling or pain of hands or feet.
• Significant weight gain.
• Black, tarry, or bloody stools.
• Blood in the urine.
• Severe constipation.
• Unusual bruising or bleeding.
• Feeling extremely tired or weak.
• Any rash.
• No improvement in condition or feeling worse.
