Antidiabetic Agent, Sulfonylurea; Antidiabetic Agent, Thiazolidinedione; Hypoglycemic Agent, Oral
• This medicine may cause or worsen heart failure. Talk with healthcare provider.
• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• Please read the medication guide.
• If you have an allergy to glimepiride, pioglitazone, or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have a sulfonamide ("sulfa") allergy, talk with healthcare provider.
• If you have any of the following conditions: Acidic blood condition, active liver disease, severely weakened heart, type 1 diabetes, or yellowing skin or eyes during troglitazone therapy.
• If you are breast-feeding.
• Pioglitazone increases insulin activity in the body.
• Glimepiride increases insulin secretion from the pancreas and may make tissues more responsive to insulin.
• Take this medicine with the first meal of the day.
• Follow diet plan and exercise program as recommended by healthcare provider.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Store at room temperature.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2006-09-28 08:38:33.0
Modified: 2010-03-09 08:29:09.0
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• Change in condition being treated. Is it better, worse, or about the same?
• Check blood sugar as directed by healthcare provider.
• Check blood work regularly. Talk with healthcare provider.
• Check weight weekly. Report a weight change to healthcare provider.
• Have a yearly eye exam and visit to the foot doctor.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• Wear disease medical alert identification.
• If you are 80 or older, use this medicine with caution. You could be more sensitive to low blood sugar.
• If you have kidney disease, talk with healthcare provider.
• If you have a weakened heart, talk with healthcare provider.
• Do not drive if blood sugar has been low. There is a greater risk of an accident.
• Be careful if you have G6PD deficiency. Anemia may occur.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Avoid alcohol (includes wine, beer, and liquor).
• Risk of pregnancy in females of childbearing age who have not been ovulating.
• Tell healthcare provider if you are pregnant or plan on getting pregnant.
• Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.
• Low blood sugar. Signs include anger, shaking, fast heartbeat, confusion, or sweating. Keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar.
• Headache.
• Weight gain.
• Nasal irritation.
• Cough.
• Swelling.
• Diarrhea.
• Weakened bones.
• Liver damage can rarely occur.
• Heart failure can occur.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.
• Very low blood sugar or very high blood sugar.
• Difficulty breathing.
• Swelling of legs or belly.
• Significant weight gain.
• Severe nausea or vomiting.
• Not able to eat.
• Dark urine or yellow skin or eyes.
• Sudden change in vision or in the way you see color.
• Feeling extremely tired or weak.
• Any rash.
• No improvement in condition or feeling worse.
