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Pyrimethamine Contributions by FoundHealth

Article Revisions

Edited Pyrimethamine Overview: Overview 14 years ago

(peer i METH a meen)

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Daraprim®

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Daraprim®

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Daraprim

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Antimalarial Agent

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• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.

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• If you have an allergy to pyrimethamine or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have anemia caused by low folic acid stores.

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• Pyrimethamine works to injure the parasite and fight the infection.

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• To gain the most benefit, do not miss doses.

• Use prescription as directed, even if feeling better.

• Take this medicine with food to prevent stomach upset.

• A liquid (suspension) is available if you cannot swallow pills. Shake well before use.

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• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

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• Change in condition being treated. Is it better, worse, or about the same?

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• Store tablets at room temperature.

• Protect tablets from moisture. Do not store in a bathroom or kitchen.

• Store liquid (suspension) at room temperature. Throw away any unused portion after 1 week.

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Edited Pyrimethamine Overview: 14 years ago

Created: 2006-10-13 15:24:37.0

Modified: 2010-05-10 14:32:04.0

Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.

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• This medicine is used to prevent or treat malaria.

• This medicine may be used to prevent or treat toxoplasmosis.

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• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

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What are the precautions when taking this medicine?

• If you are taking this medicine for more than 3 days, talk with healthcare provider.

• If you have drug or alcohol addiction, talk with healthcare provider.

• Be careful if you have G6PD deficiency. Anemia may occur.

• If you have poor absorption, talk with healthcare provider.

• If you have seizures, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Other protective measures are needed along with this medicine including using screens, bednetting, insect repellent (10% to 35% DEET), and permethrin spray on clothing and nets. Avoid spraying most insect repellents on children. Decrease evening and night-time outdoor activity.

• Folic acid may be needed to prevent side effects. Talk with healthcare provider.

• If you are pregnant or planning on getting pregnant, talk with healthcare provider. You may need even higher doses of folic acid.

• Pregnant females traveling to malaria infested areas should discuss the risks with a healthcare provider first.

• Tell healthcare provider if you are breast-feeding.

What are some possible side effects of this medicine?

• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.

• Headache.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Belly pain.

• Anemia and low platelet count can rarely occur.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Fever that occurs while in or after return from the malaria area.

• Severe dizziness or passing out.

• Severe nausea or vomiting.

• Feeling extremely tired or weak.

• Severe diarrhea.

• Any rash.

• No improvement in condition or feeling worse.

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