• This medicine may cause hepatitis.
• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• If you have an allergy to rifampin, isoniazid, pyrazinamide or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have any of the following conditions: Arthritis, high fever, gout, or liver disease.
• If you had liver damage while taking isoniazid in the past.
• Rifampin, isoniazid, and pyrazinamide work to injure the bacteria and fight the infection.
• To gain the most benefit, do not miss doses.
• Take prescription as directed, even if you are feeling better.
• Take this medicine at a similar time of day.
• Take this medicine on an empty stomach. Take 1 hour before or 2 hours after meals.
• Take this medicine with a full glass of water.
• Follow diet instructions. Certain foods and drinks taken with this medicine can cause very dangerous reactions such as sudden high blood pressure. To prevent these problems, get a list of foods to avoid from a nutritionist.
• Avoid eating aged cheeses and meats, soy sauce, soy bean including paste, Miso soup, Italian green beans (fava beans), snowpea or broad bean pods, sauerkraut, kimchee, concentrated yeast extracts (Marmite), red or white wine, and beer including alcohol-free beer.
• If medicine is stopped, follow diet for at least 2 more weeks.
• Change in condition being treated. Is it better, worse, or about the same?
• Check blood work regularly. Talk with healthcare provider.
• Have an eye exam.
• Follow up with healthcare provider.
• Store at room temperature.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2005-04-07 17:16:04.0
Modified: 2010-03-09 08:29:17.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• If you have diabetes, talk with healthcare provider.
• If you have kidney disease, talk with healthcare provider.
• If you have porphyria, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Do not take antacids within 1 hour of this medicine.
• Avoid alcohol (includes wine, beer, and liquor). Alcohol can worsen liver disease.
• Tell healthcare provider if you are pregnant or plan on getting pregnant.
• Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.
• Tell healthcare provider if you are breast-feeding.
• Change in color of body fluids to orange.
• Discoloration of contact lenses. Do not wear while taking this medicine.
• Belly pain.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Diarrhea. Yogurt, Bifidobacterium bifidum, or Lactobacillus acidophilusmay help. These products are available at health food stores or in some pharmacies.
• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
• Liver damage can rarely occur.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Severe nausea or vomiting.
• Severe diarrhea, even after medicine is stopped.
• Not able to eat.
• Dark urine or yellow skin or eyes.
• Feeling extremely tired or weak.
• Sudden change in vision, eye pain, or irritation.
• Numbness or tingling of hands or feet.
• Severe bone, joint, or muscle pain.
• Any rash.
• No improvement in condition or feeling worse.
