Romidepsin Contributions by FoundHealth

(roe mi DEP sin)

Istodax®

Antineoplastic Agent, Histone Deacetylase Inhibitor

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

• If you have an allergy to romidepsin or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you are pregnant or may be pregnant.

• If you are breast-feeding.

• Romidepsin injures cancer cells causing their death.

• This medicine is given as a shot into a vein over a period of time.

• Call healthcare provider for appointment.

• Change in condition being treated. Is it better, worse, or about the same?

• Check blood work regularly. Talk with healthcare provider.

• You may need an ECG done before starting this medicine.

• If you are diabetic, you will need to monitor blood sugars closely.

• This medicine will be given to you in a healthcare setting. You will not store it at home.

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2009-11-09 09:25:04.0

Modified: 2010-03-09 08:25:48.0

Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.

• This medicine is used to treat skin cancer from lymphoma.

What are the precautions when taking this medicine?

• If you have a fast heartbeat or are taking medicines to control your heartbeat, talk with healthcare provider.

• If you have heart disease, talk with healthcare provider.

• If you have liver disease, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Talk with healthcare provider before using aspirin, aspirin-containing products, other pain medicines, blood thinners, garlic, ginseng, ginkgo, or vitamin E.

• Tell dentists, surgeons, and other healthcare providers that you use this medicine.

• Avoid grapefruit and grapefruit juice.

• Do not take St John's wort with this medicine. It may make this medicine less effective.

• Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.

• Use birth control that you can trust to prevent pregnancy while taking this medicine.

What are some possible side effects of this medicine?

• Low blood pressure.

• Feeling tired or weak.

• Diarrhea.

• Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.

• Not hungry.

• High blood sugar.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Anemia or low platelet count can rarely occur. Medicine may need to be stopped.

• Abnormal taste. This is usually reversible.

• Low potassium level. Signs include feeling tired, weak, numbness, or tingling; muscle cramps; constipation; vomiting; or fast heartbeat.

• Risk of infection. Avoid people with infections, colds, or flu.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Difficulty breathing.

• Chest pain or pressure or fast heartbeat.

• Severe dizziness or passing out.

• Significant change in thinking clearly and logically.

• Severe headache.

• Severe nausea or vomiting.

• Severe diarrhea.

• Significant weight loss.

• Unusual bruising or bleeding.

• Feeling extremely tired or weak.

• Any rash.

• No improvement in condition or feeling worse.