• Long-term use may increase risk of cancer and serious infections.
• Sirolimus may have serious adverse effects if used for liver or lung transplantation.
• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• If you have an allergy to sirolimus or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you are pregnant or may be pregnant.
• If you are breast-feeding.
• Sirolimus helps the body accept a transplanted organ.
• It decreases the body's harmful response to diseases affecting the immune system.
All forms:
• This medicine is used in combination with other medicine to help the body accept the new organ.
• To gain the most benefit, do not miss doses.
• Take this medicine with or without food, but be consistent. Always take with food or always take on an empty stomach.
Oral solution:
• Put 1/4 cup of water or orange juice into a cup.
• Measure the medicine in the oral dose syringe. Empty medicine from syringe into cup. Mix well and drink.
• Fill container again with 1/2 cup of water or orange juice. Mix well and drink.
Tablet:
• Swallow whole. Do not chew, break, or crush.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Change in condition being treated. Is it better, worse, or about the same?
• Check blood work regularly. Talk with healthcare provider.
• Check blood pressure and heart rate regularly. Talk with healthcare provider.
Created: 2006-10-13 15:40:50.0
Modified: 2010-03-26 10:46:54.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• This medicine is used to prevent rejection after organ transplant.
• This medicine is used to treat graft versus host reactions after bone marrow transplant.
• Store tablets at room temperature.
• Protect liquid (solution) and tablets from light.
• Protect tablets from moisture. Do not store in a bathroom or kitchen.
• Store liquid (solution) at room temperature or in a refrigerator. Throw away any unused portion after 15 days if stored at room temperature. Throw away any unused portion after 1 month if refrigerated.
• Liquid (solution) may look hazy when refrigerated. Bring to room temperature and shake gently until haze goes away.
• Store liquid (solution) in a syringe at room temperature for 24 hours.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• If you have high cholesterol, talk with healthcare provider.
• If you have liver disease, talk with healthcare provider.
• If you have lung disease, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Be careful about taking vaccinations while you are receiving this medicine.
• Do not take cyclosporine capsules (Neoral®, Gengraf®) or oral solution (Neoral®) within 4 hours of this medicine.
• Avoid grapefruit and grapefruit juice.
• Use birth control that you can trust before treatment begins, during treatment, and for 3 months after treatment ends.
• You can get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen; wear protective clothing and eyewear.
• High blood pressure.
• High cholesterol level.
• Risk of infection. Avoid people with infections, colds, or flu.
• Anemia and low platelet count.
• Feeling tired or weak.
• Headache.
• Belly pain.
• Diarrhea.
• Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Swelling.
• Joint pain.
• Acne.
• Lung damage can rarely occur.
• Worsening kidney function.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.
• Difficulty breathing.
• Severe headache.
• Severe diarrhea.
• Unable to pass urine.
• Unusual bruising or bleeding.
• Any rash.
• No improvement in condition or feeling worse.
