• This medicine may cause liver problems. Blood tests will be needed to watch for any liver problems. They will be done before you start taking this medicine and every 2 weeks during treatment. If you had liver changes from this medicine in the past, do not use this medicine again. Signs of liver problems include dark urine, feeling tired, not hungry, nausea, vomiting, or yellowing of the skin or eyes. Call healthcare provider right away if you have any of these symptoms.
• If you have an allergy to tolcapone or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you are taking monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) talk with healthcare provider. Taking the two together could cause dangerously high blood pressure.
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
• Change in condition being treated. Is it better, worse, or about the same?
• If you are taking a blood thinner, check blood work (prothrombin time/INR). Talk with healthcare provider.
• Keep a diary of your symptoms.
• Check blood work (liver function). Talk with healthcare provider.
• Follow up with healthcare provider.
• Store at room temperature.
• Protect from moisture. Do not store in a bathroom or kitchen.
Created: 2006-10-13 16:04:24.0
Modified: 2010-03-22 11:08:01.0
Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• If you have liver disease, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.
• Avoid alcohol (includes wine, beer, and liquor) or other medicines and natural products that slow your actions and reactions.
• Tell healthcare provider if you are pregnant or plan on getting pregnant.
• Tell healthcare provider if you are breast-feeding.
• Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.
• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
• Extra muscle activity or slow movement. Levodopa/carbidopa may need adjustment.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Diarrhea.
• Liver damage can rarely occur.
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Significant change in thinking clearly and logically.
• Severe belly pain.
• Severe nausea or vomiting.
• Severe diarrhea.
• Not able to eat.
• Dark urine or yellow skin or eyes.
• Feeling extremely tired or weak.
• Any rash.
• No improvement in condition or feeling worse.
