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Pancreatic Cancer Contributions by Gary Wu

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Proper nutrition is extremely important, both for helping to prevent disease, and during all stages of pancreatic cancer. Because pancreatic cancer and its treatments may make it difficult to digest foods, it is important to plan one’s diet carefully.

A diet high in red meat—particularly meat that has been highly processed, preserved, charcoal broiled, or grilled—apparently increases the risk of pancreatic cancer, according to research studies. Eating more fruits, vegetables, and whole grains could reduce one’s risk.

Pancreatic cancer and pancreatic surgery interfere with digestive enzymes, and can make normal eating difficult for some time. Therefore, patients should work with their clinical dietician to determine the best diet for them in the short term and over time. Doctors may prescribe medicines to replace some digestive enzymes.

The following foods, minerals, and nutritional supplements have been identified as having some strengthening effect in battling and/or preventing cancer:

  • omega-3 fish oils
  • Vitamins C and E
  • Niacin
  • Beta carotene
  • Selenium
  • Green tea
  • Parsley
  • Whey protein
  • Pantothenic acid
  • Reservatrol
  • Melatonin
  • Perilla Oil
  • Choline
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Once pancreatic cancer has spread beyond the pancreas, it is very difficult to contain. Nonetheless, there are treatments that can significantly slow the progress of the disease, and in some cases help patients to survive for several years, especially if it is caught early.

Forms of treatment for pancreatic cancer are continually tested in clinical research trials. Treatments under study include pancreatic cancer vaccines, gene therapy, biologic therapy (drugs that stimulate the immune system to fight cancer), drugs that may prevent cancer from growing new blood vessels, and monoclonal antibodies that may inhibit the cancer’s growth.

When one takes part in a clinical trial, there may be side effects and there is no guarantee that the experimental treatment will work. However, it is a way to gain access to cutting-edge treatments that may turn out to be more effective than current ones. Also, the federal government monitors these clinical trials to ensure that they are conducted as safely as possible. If you are interested in participating in a clinical study, speak to your doctor about this possibility.

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Pancreatic cancer may be diagnosed in the following types of ways.

(Many of these procedures are also done for the purpose of staging, or measuring how far advanced the pancreatic cancer is after it has been diagnosed.)

Physical examination of the skin and the abdomen in the area of the pancreas. This includes checking for abnormal lumps, which may indicate a buildup of fluid, or ascites, which can result from the spread of cancer cells into the lymph nodes and stomach lining.

Image-Producing Procedures. There are several diagnostic tests that produce images of the pancreas and surrounding organs to detect cancer.

Laparoscopy. A laparascope is a very thin lighted tube that is inserted into the abdomen via small incisions. The laparascope carries a tiny video camera that conveys images of internal organs to a computer screen. These images are examined by a doctor.

Biopsy. Taking a biopsy means removing tissue from the pancreas (or other organ) for examination in the lab under a microscope to check for cancer. Cells and tissues can be removed from the pancreas in a number of ways, including using an endoscope as in ECRP or EUS (see Diagnostic procedures that produce images of the pancreas), inserting a needle into the pancreas, during laparoscopy, or through open abdominal surgery.

Laboratory tests, including blood, urine, and stool analysis. High levels of a substance called bilirubin in the blood, urine, or stool may indicate cancer. The presence in the blood of a protein known as CA19-9 may be a marker for pancreatic cancer, though this is not considered conclusive.

In early 2010, findings of a research study were released at the 2010 Gastrointestinal Cancers Symposium, which indicate that a protein known as PAM4 could be a very early marker for pancreatic cancer. PAM4 can be detected through a new type of blood test, which might be an effective way to screen for pancreatic cancer in people who are at high risk for the disease. This is a very hopeful development, because it signifies that the cancer could be caught and treated early, which would lead to more favorable outcomes and higher life expectancy.

REFERENCES

Mayo Clinic Staff. 2010. “Pancreatic Cancer: Tests and Diagnosis.” (Online)

http://www.mayoclinic.com/health/pancreatic-cancer/DS00357/DSECTION=tests-and-diagnosis

Laino, Charlene. WebMD Health News. 2010. “Pancreatic Cancer Detected by Blood Test.” (Online)

http://www.webmd.com/cancer/pancreatic-cancer/news/20100120/pancreatic-cancer-detected-by-blood-test

National Cancer Institute, U.S. National Institutes of Health. 2009. “Pancreatic Cancer Treatment.” (Online)

http://nci.nih.gov/cancertopics/pdq/treatment/pancreatic/Patient/page1

A.P. John Institute for Cancer Research. 2009. “Pancreatic Cancer.” (Online)

http://www.apjohncancerinstitute.org/cancer/pancreatic.htm

National Institutes of Health. 2001. “What You Need to Know About Cancers of the Pancreas.” (Online booklet)

http://nci.nih.gov/pdf/WYNTK/WYNTK_pancreas.pdf

Pancreatica.org. 2010. “Confronting Pancreatic Cancer.” (Online)

http://www.pancreatica.org/faq.html#anchor2138782

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