The Barberry plant, particularly the root and bark, have been used to treat gastrointestinal conditions and cough.
One study suggests that topical use of berberine could cause photosensitivity (an increased tendency to react to sun exposure. 1 Berberine-containing herbs should not be used by pregnant women because berberine may increase levels of bilirubin, 2 potentially damaging the fetus, and might also cause genetic damage. 3 Individuals who already have elevated levels of bilirubin (jaundice), or any other form of liver disease, should also avoid berberine-containing herbs.
Safety in young children and nursing women has not been established.
One study hints that berberine may decrease the efficacy of the drug tetracycline. 4
If you are using antibiotics in the tetracycline family, barberry might decrease their effectiveness.
Barberry is available in capsule, dried herb, tablet, tea, tincture, and tincture forms. Always check the direction on the label.
When using barberry for indigestion, liquid forms of barberry may be recommended.
The clinical research on the medicinal effects of barberry is limited. However, many laboratory studies suggest that berberine, the plant alkaloid present in barberry and other plants, may help in treating various diseases. Berberine is reported to depress intestinal paralysis and stop inflammatory congestion of the intestine's mucosal surface.
Barberry's root and bark contain alkaloids, the most prominent of which is called berberine. Some laboratory studies suggest that berberine has antimicrobial, anti-inflammatory, hypotensive, sedative, and anticonvulsant effects. The berberine found in barberry is thought to relieve abdominal pain and help with digestion by acting on the smooth muscles that line the intestines.