Celecoxib, a Cox-2 selective inhibitor, act mostly on the enzymes that are responsible for inflammation. When cells in your body are injured or damaged, a chemical called prostaglandin is released. Your nerve endings respond to the release by transmitting the pain and injury messages to the brain. This class of pain treatments relieve pain and inflammation by blocking cyclooxygenase (COX or prostaglandin synthase - PGHS), as a result, the production of prostaglandin gets impaired and relieves back pain symptoms.
There are 2 forms of cyclooxygenase, they are known as COX-1 and COX 2: COX-1 regulates normal cellular processes including gastric cytoprotection, or the mechanism that protects your stomach against injury. COX-2 is the enzyme involved in the inflammation pathway
Older NSAIDS affect both cyclooxygenases, as a result, your stomach's natural protective mechanism can get compromised, hence causing side effects such as gastric ulceration. The newer class of NSAID's, referred to as COX 2 selective inhibitors, as its name implies, act mostly on the enzymes that are responsible for inflammation while sparing COX 1. The selectivity for COX 2 reduces the risk for gastric problems while providing relief from back pain symptoms.
Celebrex is a prescription NSAID, it is available in100 mg and 200 mg capsules. The usual dose for osteoarthritis is 200 mg, taken once daily or 100 mg capsule twice a day.
Celebrex is a prescription NSAID, it is available in100 mg and 200 mg capsules. The usual dose for osteoarthritis is 200 mg, taken once daily or 100 mg capsule twice a day.
Celecoxib, a Cox-2 selective inhibitor, act mostly on the enzymes that are responsible for inflammation. When cells in your body are injured or damaged, a chemical called prostaglandin is released. Your nerve endings respond to the release by transmitting the pain and injury messages to the brain. This class of pain treatments relieve pain and inflammation by blocking cyclooxygenase (COX or prostaglandin synthase - PGHS), as a result, the production of prostaglandin gets impaired and relieves back pain symptoms.
There are 2 forms of cyclooxygenase, they are known as COX-1 and COX 2: COX-1 regulates normal cellular processes including gastric cytoprotection, or the mechanism that protects your stomach against injury. COX-2 is the enzyme involved in the inflammation pathway
Older NSAIDS affect both cyclooxygenases, as a result, your stomach's natural protective mechanism can get compromised, hence causing side effects such as gastric ulceration. The newer class of NSAID's, referred to as COX 2 selective inhibitors, as its name implies, act mostly on the enzymes that are responsible for inflammation while sparing COX 1. The selectivity for COX 2 reduces the risk for gastric problems while providing relief from back pain symptoms.
