Denosumab Side Effects and Warnings

What are the precautions when taking this medicine?

• If you have kidney disease, talk with healthcare provider.

• If you have malabsorption syndrome or have had part of your intestine removed, talk with healthcare provider.

• If you have had thyroid or parathyroid surgery, talk with healthcare provider.

• Serious infections have been reported with use of this medicine. If you have any infection, are taking antibiotics now or in the recent past, or have many infections, talk with healthcare provider.

• Tell dentists, surgeons, and other healthcare providers that you use this medicine.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Use birth control that you can trust to prevent pregnancy while taking this medicine.

What are some possible side effects of this medicine?

• Risk of infection. Avoid people with infections, colds, or flu.

• Back pain.

• Muscle pain.

• High cholesterol level.

• Skin irritation.

• Low calcium levels.

• Jaw bone damage can rarely occur.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.

• Severe jaw pain.

• Severe bone, joint, or muscle pain.

• Severe belly pain.

• Numbness or tingling around mouth.

• Numbness or tingling of hands or feet.

• Severe skin irritation.

• Any rash.

• No improvement in condition or feeling worse.