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Therapeutic Uses
Preliminary evidence suggests that DMAE may be helpful for attention deficit hyperactivity disorder ( ADHD ). 1 More widely marketed today as a memory and mood enhancer, DMAE is said to improve intellectual functioning; however, there are no clinical studies that support its use for these purposes. The basis for such claims probably stems from its purported ability to increase levels of a neurotransmitter called acetylcholine. Drugs and supplements called cholinergicsthat increase acetylcholine have been used to treat Alzheimer's disease , tardive dyskinesia , and Huntington's chorea. Because DMAE was believed to be a cholinergic, it has been tried for all of these disorders. However, well-designed double-blind, placebo-controlled studies have yielded almost entirely negative results. 2 3 4 5 6 7 In addition, there is some controversy over whether DMAE really increases acetylcholine at all. 8
References
- Re' O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp. 16(11):1238-42.
- Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia [letter]. N Engl J Med. 1974;291:797.
- Re' O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp. 16(11):1238-42.
- Alphs L, Davis JM. Noncatecholaminergic treatments of tardive dyskinesia. J Clin Psychopharmacol. 2(6):380-5.
- Soares KV, McGrath JJ. The treatment of tardive dyskinesia--a systematic review and meta-analysis. Schizophr Res. 39(1):1-16; discussion 17-8.
- Caraceni TA, Girotti F, Celano I, Parati E, Balboni L. 2-dimethylaminoethanol (Deanol) in Huntington's chorea. J Neurol Neurosurg Psychiatry. 41(12):1114-8.
- Tarsy D, Bralower M. Deanol acetamidobenzoate treatment in choreiform movement disorders. Arch Neurol. 34(12):756-8.
- Zahniser NR, Chou D, Hanin I. Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation. J Pharmacol Exp Ther. 200(3):545-59.
