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Ergotamine and Caffeine
What is it? Overview Usage Side Effects and Warnings

Ergotamine and Caffeine Overview

Written by FoundHealth.

(er GOT a meen & KAF een)

U.S. Brand Names

Cafergot®; Migergot

Canadian Brand Names


Mexican Brand Names

Cafergot; Sydolil; Trinergot

Pharmacologic Category

Antimigraine Agent; Ergot Derivative; Stimulant

What key warnings should I know about before taking this medicine?

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

Reasons not to take this medicine

• If you have an allergy to ergotamine, caffeine, or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Blood clots, heart disease, high blood pressure, kidney disease, liver disease, poor blood flow to the legs, Raynaud's disease, severe infection, or thromboangiitis obliterans.

• If you have taken almotriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, or zolmitriptan in the last 24 hours.

• If you are pregnant or may be pregnant.

• If you are breast-feeding.

How does it work?

• Ergotamine squeezes certain blood vessels in the brain preventing irritation and inflammation.

• Caffeine relieves pain.

How is it best taken?


• Take two tablets at the first sign of attack.

• Take one tablet 30 minutes after the first dose, if needed. Separate doses by at least 30 minutes.

• Do not take more than 6 tablets per attack or more than 10 tablets a week.


• Use suppository rectally.

• Do not use more than 2 suppositories per attack or more than 5 suppositories a week.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• This medicine is taken on an as needed basis.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Follow up with healthcare provider.

How should I store this medicine?

• Store at room temperature.

• Protect from moisture. Do not store in a bathroom or kitchen.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2005-04-07 16:38:19.0

Modified: 2010-03-09 08:24:10.0

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