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Safety Issues
As a widely consumed food spice, fennel is thought to have a high safety factor. However, according to one placebo-controlled study with rats, fennel impairs the absorption of the antibiotic ciprofloxacin (Cipro). 1 Fennel might be expected to interfere similarly with other drugs in the ciprofloxacin family, the fluoroquinolone drugs. Allowing 2 hours between taking ciprofloxacin and fennel should reduce the potential for an interaction, but may not eliminate it. For this reason, it may be advisable to avoid taking fennel during therapy with ciprofloxacin or other antibiotics in this family.
Maximum safe doses of fennel in young children, pregnant or nursing women, or people with severe liver or kidney disease have not been established.
Interactions You Should Know About
If you are taking:
- Drugs in the fluoroquinolone family, such as Cipro, do not use fennel.
References
- Zhu M, Wong PY, Li RC. Effect of oral administration of fennel ( Foeniculum vulgare ) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol. 1999;51:1391–6.
