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Fetal Blood Transfusion
What is it? Overview Usage Side Effects and Warnings

Fetal Blood Transfusion Overview

Written by FoundHealth.


This procedure is done when a baby that is still in the womb suffers from severe anemia . Anemia is a lack of red blood cells. When the baby's blood count falls too low, a transfusion is needed. A transfusion means giving the baby red blood cells from a donor.

There are two types of fetal blood transfusions:

  • Intravascular transfusion (IVT)—done through the mother’s abdomen into the fetus’ umbilical cord; more common procedure
  • Intraperitoneal transfusion (IPT)—done through the mother’s abdomen and uterus into the fetus’ abdomen; usually only done if IVT is impossible to do because of the position of the baby and the umbilical cord

What to Expect

Prior to Procedure

To see if the fetus has severe anemia or fetal hydrops, the doctor may do these tests:

  • Amniocentesis —a sample of amniotic fluid is taken
  • Cordocentesis—a blood sample from the umbilical cord is taken
  • Ultrasound —a test that uses sound waves to examine the internal organs

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If the fetus has hydrops, the blood transfusion will be done right away.

Before the transfusion, you may be given:

  • Pain medicine
  • Muscle relaxant through an injection or an IV


Local anesthesia—numbs a small area of your abdomen

Description of the Procedure

With IVT, the fetus will be paralyzed for a short time. This is to allow access to fetal blood vessels and to reduce injury to the fetus. During both IVT and IPT, the doctor will monitor the fetus with an ultrasound scan. The ultrasound will:

  • Show the position of the fetus
  • Guide the placement of the needle through the amniotic sac and into the vessel in the umbilical cord
  • Record the fetal heart rate

The doctor will insert a needle into your abdomen. Using ultrasound, the doctor will make sure the needle is placed correctly. The needle will go through your abdomen and be inserted into the umbilical cord (IUT) or into the fetal abdomen (IPT). Blood will be transfused to the fetus.

Before the needle is removed, the doctor will take a final blood sample. This is to determine the fetus' blood level (called hematocrit). The doctor will find out whether the transfusion was enough and when the next one should be.

The transfusions may need to be repeated every 2-4 weeks until your doctor decides that it is safe to deliver the baby.

How Long Will It Take?

A 10 ml IVT transfusion will take 1-2 minutes. Usually, between 30-200 ml is transfused during a single procedure.

How Much Will It Hurt?

You will feel pain and cramping where the doctor inserts the needle. If you are close to delivering the baby or if the procedure is long, the uterus will be sore.

Average Hospital Stay

This procedure is done in a hospital setting. You will be able to go home after the transfusion. If complications occur, you may need to have a C-section.

Post-procedure Care

The doctor may give you:

  • Antibiotics to prevent infection
  • Medicine to prevent contractions or labor

Be sure to follow your doctor’s instructions.

Once your baby has finally delivered, the baby will need to have follow-up blood tests. The doctor will closely monitor the baby for:

  • Anemia
  • Liver damage
  • Congestive heart failure
  • Respiratory failure
  • Other complications if the baby is premature



The American Congress of Obstetricians and Gynecologists

American Pregnancy Association

March of Dimes


Save Babies Through Screening Foundation of Canada

Women's Health Matters


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