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Because it occurs naturally in foods and is a part of most people's regular diet, fiber is considered to be generally safe at normal amounts. Some people do experience digestive upset (stomach ache, cramps, and/or diarrhea) when they increase their intake of fiber. To avoid this, increase your intake gradually so your body has time to adjust.
There are some theoretical concerns about the use of beta-glucan and its potential effects on the immune system. For more information, see the the Side Effects & Warnings section of the beta glucan article.