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Generalized Anxiety Disorder and Arginine

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Arginine is an amino acid found in many foods, including dairy products, meat, poultry, and fish. It plays a role in several important mechanisms in the body, including cell division, wound healing, removal of ammonia from the body, immunity to illness, and the secretion of important hormones.

The body also uses arginine to make nitric oxide (NO), a substance that relaxes blood vessels and also exerts numerous other effects in the body. Based on this, arginine has been proposed as a treatment for various cardiovascular diseases, including congestive heart failure and intermittent claudication, as well as impotence, female sexual dysfunction, interstitial cystitis, and many other conditions. Arginine's potential effects on immunity have also created an interest in using it as part of an "immune cocktail" given to severely ill hospitalized patients and also for preventing colds.

Effect of Arginine on Generalized Anxiety Disorder

Classified as a semi-essential amino acid, Arginine when used in combination with Lysine might be useful for helping treat anxiety.

Read more details about Arginine.

Research Evidence on Arginine

One study found that week-long oral treatment with lysine (2.64 g per day) and arginine (2.64 g per day) could reduce general levels of anxiety.57

Safety Issues

There is good evidence that arginine is safe and well tolerated at levels up to 20 g per day, 1 although minor gastrointestinal upset can occur. However, there are some potential safety issues regarding high-dose arginine. These cautions are based on findings from animal studies and hospital experiences of intravenous administration.

For example, arginine may stimulate the body's production of gastrin, a hormone that increases stomach acid. 2 For this reason, there are concerns that arginine could be harmful for people with ulcers or who take drugs that are hard on the stomach. In addition, a double-blind trial found that arginine (30 g/day) may increase the risk of esophageal reflux (heartburn) by relaxing the sphincter at the bottom of the esophagus. 3 Arginine might also alter potassium levels in the body, especially in people with severe liver disease. 4 This is a potential concern for individuals who take drugs that also alter potassium balance (such as potassium-sparing diuretics and ACE inhibitors ), as well as those with severe kidney disease. If you fall into any of these categories, do not use high-dose arginine except under physician supervision.

Evidence that arginine can improve insulin sensitivity 5 raises theoretical concerns that, if you have diabetes and take arginine, your blood sugar could fall too low. However, one study suggests that arginine is safe for use by people with stable type 2 (adult-onset) diabetes. 6 The amino acid lysine has been advocated for use in oral or genital herpes . According to the theory behind this recommendation, it is important to simultaneously restrict arginine intake. If true, this would tend to suggest that arginine supplements would be harmful for people with a tendency to develop herpes. However, there is no meaningful evidence to support this hypothesis.

Maximum safe doses in pregnant or nursing women, young children, and those with severe liver or kidney disease have not been established.

Interactions You Should Know About

If you are taking:

  • Lysine to treat herpes: Arginine might counteract the potential benefit. 7
  • Drugs that are hard on the stomach (such as nonsteroidal anti-inflammatory medications ): Taking high doses of arginine might stress your stomach additionally.
  • Medications that can alter the balance of potassium in your body (such as potassium-sparing diuretics or ACE inhibitors ): High doses of arginine should be used only under physician supervision.
  • Transdermal nitroglycerin : Arginine may help prevent the development of tolerance. ( Note: Your doctor's supervision is essential.)


  1. Shao A, Hathcock JN. Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regul Toxicol Pharmacol. 50(3):376-99.
  2. AHFS Drug Information. Bethesda, MD: American Society of Hospital Pharmacists. 2000:2306-2307.
  3. Luiking YC, Weusten BL, Portincasa P, Van Der Meer R, Smout AJ, Akkermans LM. Effects of long-term oral L-arginine on esophageal motility and gallbladder dynamics in healthy humans. Am J Physiol. 274(6 Pt 1):G984-91.
  4. AHFS Drug Information. Bethesda, MD: American Society of Hospital Pharmacists. 2000:2306-2307.
  5. Piatti PM, Monti LD, Valsecchi G, Magni F, Setola E, Marchesi F, Galli-Kienle M, Pozza G, Alberti KG. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 24(5):875-80.
  6. Bruinsma KA, Anderson BE, Prendergast JJ, et al. Effects of an L-arginine-enriched medical food in patients with type II diabetes [abstract]. Diabetes. 2001;50(suppl 2):1796-PO.
  7. Griffith RS, DeLong DC, Nelson JD. Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 27(3):209-13.
  1. Smriga M, Ando T, Akutsu M, et al. Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. Biomed Res. 2007;28:85-90.

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