What is it? Overview Usage Side Effects and Warnings

Glucosamine Usage

Written by FoundHealth.


Effect of Glucosamine on Osteoarthritis

Glucosamine appears to stimulate cartilage cells in the joints to make proteoglycans and collagen, two proteins essential for the proper function of joints.6-10 Glucosamine may also help prevent...

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Effect of Glucosamine on Low Back Pain and Sciatica

Glucosamine, most commonly used in the form glucosamine sulfate, is a simple molecule derived from glucose, the principal sugar found in blood. In glucosamine, one oxygen atom in glucose is replaced...

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Therapeutic Uses

Glucosamine is widely accepted as a treatment for osteoarthritis . However, the current evidence from double-blind studies is highly inconsistent, with many of the most recent and best-designed studies failing to find significant benefit. 1 According to the positive studies, glucosamine acts more slowly than conventional treatments, such as ibuprofen, but eventually produces approximately equivalent benefits. In addition, unlike conventional treatments, glucosamine might also help prevent progressive joint damage, thereby slowing the course of the disease. 2 However, both these potential benefits remain controversial in light of the most recent trials.

Glucosamine has also shown some promise for osteochondritis of the knee, a cartilage disease related to osteoarthritis. 3 Some athletes use glucosamine, in the (unproven) belief that it can prevent muscle and tendon injuries . It has also been suggested as a treatment for tendonitis . However, there is no meaningful scientific evidence to support these potential uses. Exercise can also produce short-term muscle soreness. In one study, use of glucosamine not only failed to prove effective for reducing this type of pain, it actually increasedit. 4 However, one study found somewhat inconsistent evidence hinting that glucosamine might aid recovery from acute knee injuries experienced by competitive athletes. 5 Glucosamine might also be helpful for rheumatoid arthritis , according to a double-blind, placebo-controlled study of 51 people. 6 In this study, use of glucosamine at a dose of 1,500 mg daily significantly improved symptoms. It did not, however, alter measures of inflammation as determined through blood tests.


  1. Noack W, Fischer M, Förster KK, Rovati LC, Setnikar I. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage. 2(1):51-9.
  2. Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 357(9252):251-6.
  3. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med. 37(1):45-9; discussion 49.
  4. Arendt-Nielsen L, Weidner M, Bartholin D, Rosetzsky A. A double-blind randomized placebo controlled parallel group study evaluating the effects of ibuprofen and glucosamine sulfate on exercise induced muscle soreness. J Musculoskelet Pain. 2007;15:21-28.
  5. Ostojic SM, Arsic M, Prodanovic S, Vukovic J, Zlatanovic M. Glucosamine administration in athletes: effects on recovery of acute knee injury. Res Sports Med. 15(2):113-24.
  6. Nakamura H, Masuko K, Yudoh K, Kato T, Kamada T, Kawahara T. Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int. 27(3):213-8.


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