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Safety Issues
No serious adverse effects from using glycine have been reported, even at doses as high as 60 g per day. One participant in the 22-person trial described above developed stomach upset and vomiting, but it ceased when the glycine was discontinued.
In contradiction to the study on strokes mentioned above, theoretical concerns have been raised that suggest glycine might actually increase brain injury in strokes. 1 In fact, drugs that block glycine have been investigated as treatments to limit stroke damage. 2 However, the authors of the study on strokes described above make an argument that suggests the overall effect of glycine is protective. 3 Until this controversy is settled, prudence suggests not using glycine following a stroke, except on the advice of a physician.
In addition, as noted above, it is possible that use of glycine could reduce the benefits of clozapine.
Maximum safe doses for young children, pregnant or nursing women, or people with liver or kidney disease are not known.
Interactions You Should Know About
If you are taking:
- Clozapine : Do not take glycine except on the advice of a physician.
References
- Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Lichtenstein M. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 56(1):29-36.
- Sopala M, Schweizer S, Schäfer N, Nürnberg E, Kreuter J, Seiller E, Danysz W. Neuroprotective activity of a nanoparticulate formulation of the glycineB site antagonist MRZ 2/576 in transient focal ischaemia in rats. Arzneimittelforschung. 52(3):168-74.
- Gusev EI, Skvortsova VI, Dambinova SA, Raevskiy KS, Alekseev AA, Bashkatova VG, Kovalenko AV, Kudrin VS, Yakovleva EV. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis. 10(1):49-60.
