Gonadotropin-Releasing Hormone (GnRH) Side Effects and Warnings

Side effects and cautions

When given with ovulation-stimulating treatment, GnRH analogues don't cause low-estrogen symptoms. But when taken alone, GnRH analogues may cause a temporary condition which has the same effects as menopause, such as:

• hot flashes
• mood swings
• decreased sexual interest
• vaginal dryness
• increased low-density lipoprotein (LDL) cholesterol level
• decreased high-density lipoprotein (HDL)
• cholesterol
• insomnia and
• headaches.

These side effects will go away when you stop using a GnRH agonist

GnRH antagonist therapy can cause: * nausea or * swelling, redness, or itching at the injection site.