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Gout and Pegloticase

Written by sshowalter.

Effect of Pegloticase on Gout

Common brand name: Krystexxa

Pegloticase has been approved by the Food and Drug Administration (FDA) to treat adults who have severe gout that has not been relieved by other treatments. This medicine works by turning uric acid into a chemical that does not cause gout symptoms. This chemical leaves the body through the urine. Pegloticase is given by injection every two weeks.

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Since severe allergic reactions are common with this medicine, a corticosteroid and an antihistamine are given before the injection of pegloticase.

Other possible side effects include:

  • Flare-up of gout
  • Nausea and vomiting
  • Constipation
  • Bruise at the injection site
  • Nasal irritation
  • Chest pain

The medicine has not been studied in people who have congestive heart failure. Consult your practitioner before going on this or any other medication.


Effect of Nonsteroidal Anti-inflammatory Agents (NSAIDs) on Gout

Common names include:

  • Ibuprofen (Apo-Ibuprofen)
  • Indomethacin (Indocin)
  • Naproxen (Aleve)
  • Diclofenac (Cataflam)

NSAIDs are given to treat the pain, inflammation, and...

Read more about Gout and Nonsteroidal Anti-inflammatory Agents (NSAIDs).

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