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As a commonly consumed condiment, horseradish is believed to be relatively safe. However, because of its spicy nature, it can cause burning mouth pain, sweating, and gastrointestinal distress. Left too long in contact in the skin, marked irritation may develop. It is definitely not advisable to get horseradish products in contact with the eyes.
Maximum safe doses of horseradish have not been established for pregnant or nursing women, young children, or people with serious liver or kidney disease.