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Hyaluronate and Derivatives
What is it? Overview Usage Side Effects and Warnings

Hyaluronate and Derivatives Overview

Written by FoundHealth.

(hye al yoor ON ate & dah RIV ah tives)

U.S. Brand Names

Bionect®; Euflexxa™; Healon GV®; Healon®; Healon®5; Hyalgan®; Hylaform®; Hylaform® Plus; Hylira™; IPM Wound Gel™ [OTC]; Juvederm™ 24HV; Juvederm™ 30; Juvederm™ 30HV; Orthovisc®; Perlane®; Provisc®; Restylane®; Supartz™; Synvisc-One™; Synvisc®; Vitrax®

Canadian Brand Names

Cystistat®; Durolane®; Eyestil; Healon GV®; Healon®; OrthoVisc®; Suplasyn®

Mexican Brand Names


Pharmacologic Category

Antirheumatic Miscellaneous; Ophthalmic Agent, Viscoelastic; Skin and Mucous Membrane Agent, Miscellaneous

Reasons not to take this medicine

• If you have an allergy to hyaluronic acid or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have an allergy to birds or eggs, talk with healthcare provider.


• If you have an infected joint.


• If you are less than 18 years of age.

• If you have a skin infection.

How does it work?


• This medicine helps provide a better surface for eye surgery.


• This medicine loosens the joint area around the knee.

Skin injection:

• This medicine restores volume and thickness to skin lessening wrinkles and folds.


• This medicine helps the skin maintain moisture which helps with wound healing.

How is it best taken?


• This medicine is given as a shot into the eye.


• This medicine is given as a shot into the knee.

Skin injection:

• This medicine is given as a shot into the skin of the face.


• Do not take this medicine by mouth. For skin only. Keep out of mouth, nose, and eyes (may burn).

• Wash hands before and after use.

• Clean affected area before use. Make sure to dry well.

• Apply a thin layer to the affected skin.

• Cover the wound with a clean dressing.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Call healthcare provider for appointment.

Skin topical:

• Apply a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not apply a double dose or extra doses.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

How should I store this medicine?

Skin gel:

• Store at room temperature.

Eye, Knee, Skin (injection):

• This medicine will be given to you in a healthcare setting. You will not store it at home.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2006-10-13 13:02:36.0

Modified: 2010-03-22 14:01:44.0

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