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Hydroxymethyl Butyrate (HMB)
What is it? Overview Usage Side Effects and Warnings

Hydroxymethyl Butyrate (HMB) Usage

Written by FoundHealth.

Therapeutic Uses

According to some but not all of the small double-blind trials performed thus far, HMB may improve response to weight training. 1 One small double-blind, placebo-controlled trial found hints that HMB might help prevent muscle damage during prolonged exercise, thereby potentially enhancing recovery during athletic training ; 2 however, a follow-up study failed to find this benefit. 3 A very small study found evidence that HMB might improve aerobic exercise capacity. 4 Very weak evidence suggests that HMB might improve blood pressure and cholesterol levels. 5


  1. Ostaszewski P, Kostiuk S, Balasinska B, et al. The effect of leucine metabolite 3-hydroxy-3-methylbutyrate (HMB) on muscle protein synthesis and protein breakdown in chick and rat muscle [abstract]. J Anim Sci. 1996;74(suppl 1):138.
  2. Knitter AE, Panton L, Rathmacher JA, Petersen A, Sharp R. Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol. 89(4):1340-4.
  3. Hoffman JR, Cooper J, Wendell M, Im J, Kang J. Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training. J Strength Cond Res. 18(4):747-52.
  4. Lamboley CR, Royer D, Dionne IJ. Effects of beta-hydroxy-beta-methylbutyrate on aerobic-performance components and body composition in college students. Int J Sport Nutr Exerc Metab. 17(1):56-69.
  5. Nissen S, Sharp RL, Panton L, Vukovich M, Trappe S, Fuller JC Jr. beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J Nutr. 130(8):1937-45.


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