What is it? Overview Usage Side Effects and Warnings

Inositol Usage

Written by FoundHealth.


Effect of Inositol on Polycystic Ovarian Syndrome

Mostly, inositol might be helpful in treating PCOS for those with insulin resistance.

Read more about Polycystic Ovarian Syndrome and Inositol.

Effect of Inositol on Bipolar Disorder

Inositol may be used to help treat bipolar disorder, and may also be prescribed to reduce psoriasis symptoms caused by lithium.21

Read more about Bipolar Disorder and Inositol.

Therapeutic Uses

Some but not all studies suggest that high-dose inositol may be useful for depression . 1 2 3 Inositol has also been studied for bipolar disorder , 4 panic disorder , 5 bulimia , 6 and obsessive-compulsive disorder , 7 but the evidence remains far from conclusive. Other potential uses include Alzheimer's disease 8 and attention deficit disorder . 9 According to two double-blind studies enrolling a total of almost 400 people, inositol may help improve various symptoms of polycystic ovary syndrome , including infertility and weight gain. 10 Another very small double-blind study found that inositol supplements could help reduce symptoms of psoriasis triggered or made worse by use of the drug lithium . 11 A small double-blind study failed to find inositol helpful for premenstrual dysphoric disorder, a severe form of premenstrual syndrome (PMS) . 12 Inositol is sometimes proposed as a treatment for diabetic neuropathy , but there have been no double-blind, placebo-controlled studies on this subject, and two uncontrolled studies had mixed results. 13 Inositol has also been investigated for potential cancer-preventive properties. 14 15 16 17 18 19 20


  1. Levine J, Barak Y, Kofman O, Belmaker RH. Follow-up and relapse analysis of an inositol study of depression. Isr J Psychiatry Relat Sci. 32(1):14-21.
  2. Levine J. Controlled trials of inositol in psychiatry. Eur Neuropsychopharmacol. 7(2):147-55.
  3. Benjamin J, Agam G, Levine J, Bersudsky Y, Kofman O, Belmaker RH. Inositol treatment in psychiatry. Psychopharmacol Bull. 31(1):167-75.
  4. Chengappa KN, Levine J, Gershon S, Mallinger AG, Hardan A, Vagnucci A, Pollock B, Luther J, Buttenfield J, Verfaille S, Kupfer DJ. Inositol as an add-on treatment for bipolar depression. Bipolar Disord. 2(1):47-55.
  5. Benjamin J, Levine J, Fux M, Aviv A, Levy D, Belmaker RH. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry. 152(7):1084-6.
  6. Gelber D, Levine J, Belmaker RH. Effect of inositol on bulimia nervosa and binge eating. Int J Eat Disord. 29(3):345-8.
  7. Fux M, Levine J, Aviv A, Belmaker RH. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry. 153(9):1219-21.
  8. Levine J. Controlled trials of inositol in psychiatry. Eur Neuropsychopharmacol. 7(2):147-55.
  9. Levine J. Controlled trials of inositol in psychiatry. Eur Neuropsychopharmacol. 7(2):147-55.
  10. Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 7(6):151-9.
  11. Allan SJ, Kavanagh GM, Herd RM, Savin JA. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol. 150(5):966-9.
  12. Nemets B, Talesnick B, Belmaker RH, Levine J. Myo-inositol has no beneficial effect on premenstrual dysphoric disorder. World J Biol Psychiatry. 3(3):147-9.
  13. Salway JG, Whitehead L, Finnegan JA, Karunanayaka A, Barnett D, Payne RB. Effect of myo-inositol on peripheral-nerve function in diabetes. Lancet. 2(8103):1282-4.
  14. Wattenberg LW. Chemoprevention of pulmonary carcinogenesis by myo-inositol. Anticancer Res. 19(5A):3659-61.
  15. Dong Z, Huang C, Ma WY. PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer. Anticancer Res. 19(5A):3743-7.
  16. Yang GY, Shamsuddin AM. IP6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: involvement of intracellular inositol phosphates. Anticancer Res. 15(6B):2479-87.
  17. Ishikawa T, Nakatsuru Y, Zarkovic M, Shamsuddin AM. Inhibition of skin cancer by IP6 in vivo: initiation-promotion model. Anticancer Res. 19(5A):3749-52.
  18. Shamsuddin AM. Metabolism and cellular functions of IP6: a review. Anticancer Res. 19(5A):3733-6.
  19. Shamsuddin AM, Vucenik I. Mammary tumor inhibition by IP6: a review. Anticancer Res. 19(5A):3671-4.
  20. Vucenik I, Kalebic T, Tantivejkul K, Shamsuddin AM. Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res. 18(3A):1377-84.


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