Ipilimumab Side Effects and Warnings

Ipilimumab (sold as Yervoy) has side effects that come from the activation of T-cells and the body’s immune responses. The most common are side effects are very much like auto-immune disorders and include a number of adverse reactions including diarrhea, rash, fatigue, nausea, vomiting, decreased appetite, and abdominal pain. In the clinical trials, Ipilimumab use was stopped in 10% of the patients due to the severity of the side effects. Ipilimumab side effects varied widely with the test population, and can appear after the drug use is stopped. Sensitive patients were given hydrocortisone to reduce the immune system activity.^1,3,4,7,9

• Black Box Warning for Ipilimumab