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Ketorolac Tromethamine
What is it? Overview Usage Side Effects and Warnings

Ketorolac Tromethamine Overview

Written by FoundHealth.

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U.S. Brand Names

Acular LS®; Acular®; Acular® PF [DSC]; Acuvail™

Canadian Brand Names

Acular LS®; Acular®; Apo-Ketorolac Injectable®; Apo-Ketorolac®; Ketorolac Tromethamine Injection, USP; Novo-Ketorolac; Nu-Ketorolac; ratio-Ketorolac; Toradol®; Toradol® IM

Mexican Brand Names

Alidol; Dolac; Estopein; Supradol; Toloran; Toral; Torkol

Pharmacologic Category

Nonsteroidal Anti-inflammatory Drug (NSAID), Ophthalmic; Nonsteroidal Anti-inflammatory Drug (NSAID), Oral; Nonsteroidal Anti-inflammatory Drug (NSAID), Parenteral

What key warnings should I know about before taking this medicine?

• This medicine may increase the risk of heart attack, stroke, and high blood pressure. This has been observed with long-term use or at critical times (right after heart surgery). Use caution if you have risk factors for heart disease (high blood pressure, high cholesterol, overweight, diabetes, cigarette smoking, male older than 40 years of age, other family members with early heart disease, postmenopausal female).

• Do not use this medicine right before or after heart bypass surgery.

• This medicine may increase the risk of ulcer or bleeding from the stomach or intestines. Talk with healthcare provider.

• This medicine is only to be used for 5 days total. It is for severe, short-term pain. It may cause severe side effects if taken longer than 5 days. Let healthcare provider know if you have ulcer disease, kidney disease, a risk of bleeding or any active bleeding, allergies to ketorolac, aspirin, or any other pain medicine. Do not take if you are pregnant or breast-feeding. Tell healthcare provider if you are 65 years of age or older or weigh less than 110 pounds.

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

• Please read the medication guide.

Reasons not to take this medicine

• If you have an allergy to ketorolac tromethamine or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Bleeding in the brain, bleeding problems, hole in the gastrointestinal tract, recent gastrointestinal bleeding, severe kidney disease, ulcer disease, or use before major surgery.

• If you are more than 24 weeks pregnant.

• If you are breast-feeding.

How does it work?

• Ketorolac tromethamine blocks production and release of chemicals that cause pain and inflammation.

How is it best taken?


• Take this medicine with food to prevent stomach upset.


• For the eye only.

• Wash hands before and after use.

• Take out contact lenses before using medicine. Lenses can be replaced 15 minutes after medicine is given. Do not put contacts back in if eyes are irritated or infected.

• Do not touch the container tip to the eye, lid, or other skin.

• Tilt head back and drop medicine into eye.

• After using medicine, keep your eyes closed. Apply pressure to the inside corner of the eye. Do this for 3-5 minutes. This keeps the medicine in your eye.

• Separate each eye medicine by 5 minutes.


• This medicine is given as a shot into a muscle or vein.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

• Many times this medicine is taken on an as needed basis.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Follow up with healthcare provider.

How should I store this medicine?

• Store at room temperature.

• Protect from light.

• Protect tablets from moisture. Do not store in a bathroom or kitchen.

• This medicine will be given to you in a healthcare setting. You will not store it at home.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2006-10-13 13:26:19.0

Modified: 2010-03-22 14:34:56.0

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