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Lipoic acid appears to have no significant side effects at dosages up to 1,800 mg daily. 1 Safety for young children, women who are pregnant or nursing, or those with severe liver or kidney disease has not been established.
- Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Diabetes Care. 1999;22:1296-1301.