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What is it? Overview Usage Side Effects and Warnings

Lysine Side Effects and Warnings

Written by FoundHealth.

Safety Issues

Although lysine is an essential part of the diet, the safety of concentrated lysine supplements has not been well studied. In animal studies, high dosages have caused gallstones and elevated cholesterol levels, 1 so you may want to use caution when using lysine if you have either of these problems. Maximum safe dosages for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been established.

Interactions You Should Know About

If you are taking lysine to treat herpes, arginine might counteract the potential benefit. 2


  1. Kritchevsky D, Weber MM, Klurfeld DM. Gallstone formation in hamsters: Influence of specific amino acids. Nutr Rep Int. 1984;29:117-121.
  2. Griffith RS, DeLong DC, Nelson JD. Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 27(3):209-13.


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