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As a sugar widely present in foods, mannose is assumed to be safe. However, the maximum safe dosage has not been established in healthy adults, nor in pregnant or nursing women or young children. Very weak evidence from test tube studies hints that consumption of gigantic amounts of mannose by pregnant women could conceivably increase risk of birth defects in their offspring. 1 2
- Freinkel N, Lewis NJ, Akazawa S, Gorman L, Potaczek M. The honeybee syndrome: teratogenic effects of mannose during organogenesis in rat embryo culture. Trans Assoc Am Physicians. 96():44-55.
- Freinkel N, Lewis NJ, Akazawa S, Roth SI, Gorman L. The honeybee syndrome - implications of the teratogenicity of mannose in rat-embryo culture. N Engl J Med. 310(4):223-30.