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Because it seems to discourage bacteria from sticking to the wall of the bladder, methionine has been suggested as a treatment for recurrent bladder infections . 1 However, the evidence that it works is limited to one small trial without a placebo control. (For information on why placebo-controlled trials are essential to prove a treatment effective, see Why Does This Database Depend on Double-Blind Studies? )
One double-blind study found equiviocal evidence that methionine supplements taken at a dose of 2.4 g per day might improve immune function in people with HIV . 2 One study on rats suggests that methionine might protect the liver against the damaging effects of acetaminophen poisoning. 3 On this slim basis, methionine has been proposed as a general liver protectant . However, in this particular study, the action of methionine was more to fight acetaminophen specifically than to protect the liver in general.
Very preliminary evidence suggests methionine might be helpful in treating Parkinson's disease . 4 However, this should not be attempted except under physician supervision; see Safety Issues.
- Funfstuck R, Straube E, Schildbach O, et al. Prevention of reinfection by L-methionine in patients with recurrent urinary tract infection [in German]. Med Klin. 1997;92:574-581.
- Van Brummelen R, du Toit D. L-methionine as immune supportive supplement: a clinical evaluation. Amino Acids. 33(1):157-63.
- Neuvonen PJ, Tokola O, Toivonen ML, Simell O. Methionine in paracetamol tablets, a tool to reduce paracetamol toxicity. Int J Clin Pharmacol Ther Toxicol. 23(9):497-500.
- Smythies JR, Halsey JH. Treatment of Parkinson's disease with L-methionine. South Med J. 77(12):1577.