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What is it? Overview Usage Side Effects and Warnings

Mitoxantrone Overview

Written by FoundHealth.

(mye toe ZAN trone)

U.S. Brand Names


Canadian Brand Names

Mitoxantrone Injection®; Novantrone®

Mexican Brand Names

Mitoxgen; Mitroxone

Pharmacologic Category

Antineoplastic Agent, Anthracenedione

What key warnings should I know about before taking this medicine?

• This medicine may cause damage to your heart in certain situations. Talk with healthcare provider. Patients with liver disease need a lower dose. This medicine can have severe effects on the bone marrow. The bone marrow may not be able to produce the cells found in the blood as well as it used to. You will be closely monitored by healthcare provider. The risk of cancer is higher after taking this medicine.

• This medicine may irritate or damage the vein.

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

• This medicine is given as a shot into a vein only.

Reasons not to take this medicine

• If you have an allergy to mitoxantrone or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Bone marrow disease or a severely weakened heart.

• If you have received a full treatment with daunorubicin, doxorubicin, epirubicin, or idarubicin.

• If you have received the maximum lifetime dose already. This may vary, talk with healthcare provider.

• If you are pregnant or may be pregnant.

• If you are breast-feeding.

How does it work?

• Mitoxantrone injures cancer cells causing their death.

• It decreases the body's harmful response to diseases affecting the immune system.

How is it best taken?

• This medicine is given into a vein constantly for a period of time.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Call healthcare provider for appointment.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Heart function tests. Talk with healthcare provider.

• Check blood work regularly. Talk with healthcare provider.

• Check weight weekly. Report a weight loss to healthcare provider.

• Follow up with healthcare provider.

How should I store this medicine?

• This medicine will be given to you in a healthcare setting. You will not store it at home.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2005-04-07 17:00:58.0

Modified: 2010-03-09 08:29:42.0

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