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NAC appears to be a very safe supplement when taken alone, although one study in rats suggests that 60 to 100 times the normal dose can cause liver injury. 1 As mentioned above, the combination of nitroglycerin and NAC can cause severe headaches. Safety in young children, women who are pregnant or nursing, and individuals with severe liver or kidney disease has not been established.
Interactions You Should Know About
If you are taking nitroglycerin, NAC may cause severe headaches.
- Badawy AH, Abdel Aal SF, Samour SA. Liver injury associated with N-acetylcysteine administration. J Egypt Soc Parasitol. 19(2):563-71.