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Osteoarthritis and Methylsulfonylmethane

Written by sshowalter.

Effect of Methylsulfonylmethane on Osteoarthritis

The supplement methyl sulfonyl methane (MSM) has shown promise for osteoarthritis when taken along with glucosamine.138

Besides that study, benefits were also seen in a 12-week, double-blind, placebo-controlled trial of 50 people with osteoarthritis, utilizing MSM at a dose of 3 g twice daily.155

However, in a comprehensive review of 6 studies involving 681 patients with osteoarthritis of knee, researchers concluded it is not yet possible to convincingly determine whether or not either DSMO or MSM is beneficial.197

Read more details about Methylsulfonylmethane.


  1. Usha P.R., Naidu M.U.R. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation. 2004;24:353-363.
  2. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2005 Nov 22. [Epub ahead of print]
  3. Brien S, Prescott P, Bashir N, et al. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2008 Apr 14.

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