Find us on Social Media:

What is it? Overview Usage Side Effects and Warnings

Oxerutins Overview

Written by FoundHealth.

Oxerutins are a group of chemicals derived from a naturally occurring bioflavonoid called rutin.

This supplement has been widely used in Europe since the mid-1960s, as a treatment for conditions in which blood or lymph vessels leak fluid. Considerable evidence suggests that oxerutins are effective. Unfortunately, it is difficult to find this supplement in North America.


Although they are closely related to a natural flavonoid, oxerutins are not found in food. The only way to take them is in a supplement.

Therapeutic Dosages

For varicose veins/venous insufficiency , oxerutins are usually taken in dosages ranging from 900 mg to 1,200 mg daily. A typical schedule is 1,000 mg daily, taken in two separate doses of 500 mg.

For treating lymphedema and postsurgical edema , a typical dosage is a good deal higher: 3,000 mg daily.

One particular oxerutin called troxerutin may be taken alone (in similar dosages) as a treatment for varicose veins. There is no evidence as yet that rutin itself is effective.

What Is the Scientific Evidence for Oxerutins?

Varicose Veins/Venous Insufficiency

About 20 double-blind, placebo-controlled studies, enrolling a total of more than 2,000 participants, have examined oxerutins' effectiveness for treating varicose veins and venous insufficiency. Virtually all found oxerutins significantly more effective than placebo, giving substantial relief from swelling, aching, leg pains, and other uncomfortable symptoms, while causing no significant side effects.

For example, one large double-blind, placebo-controlled study published in 1983 enrolled 660 people with symptoms of venous insufficiency. 1 Three out of four participants were randomly assigned to receive oxerutins (1,000 mg daily) while one out of four was given placebo. After 4 weeks of treatment, those who took oxerutins reported less heaviness, aching, cramps, and "restless leg" or "pins and needles" symptoms than those who took placebo. According to the researchers' calculations, oxerutins had produced significantly better results than placebo. This report has been criticized, however, for omitting key information (such as whether or not any participants also wore support stockings) and for failing to present data in a usable form.

A more recent, better-designed study supported these positive findings. 2 This 12-week, double-blind, placebo-controlled study enrolled 133 women with moderate chronic venous insufficiency. Half received 1,000 mg oxerutins daily, and the rest took a matching placebo. All participants were also fitted with standard compression stockings and wore them for the duration of the study. The researchers measured subjective symptoms, such as aches and pains, as well as objective measures of edema in the leg.

Those who took oxerutins had significantly less lower-leg edema than the placebo group. Furthermore, these results lasted through a 6-week follow-up period, even though participants were no longer taking oxerutins. Compression stockings, on the other hand, produced no lasting benefit after participants stopped wearing them. They gave symptomatic relief while they were worn, but they didn't improve capillary circulation in a lasting way, as oxerutins apparently did.

Regarding aching, sensations of heaviness, and other uncomfortable symptoms, however, there was little difference between the two groups. The authors theorized that the compression stockings gave both groups so much symptomatic relief that it was difficult to demonstrate a separate subjective benefit of oxerutin therapy.

Many other double-blind, placebo-controlled studies have also found benefits with oxerutins for varicose veins and venous insufficiency. 3 As mentioned above, there is some evidence that troxerutin—one of the compounds in the standardized mixture sold as oxerutins—may be effective when taken alone. One study found it more effective than placebo, 4 but another (very small) study found it less effective than the standard oxerutin mixture. 5 Pregnant women are at especially high risk for varicose veins and venous insufficiency. A 1975 study examined 69 pregnant women with varicose leg veins, and found that oxerutins (900 mg daily) were significantly more effective than placebo against pain as well as swelling. 6 A more recent study also found positive results, 7 but because it was neither placebo-controlled nor double-blind its results mean little (other than to suggest that oxerutins are safe in pregnancy).

Skin ulcers sometimes form on the legs of people with varicose veins or venous insufficiency, when capillary circulation has become too impaired to keep the skin healthy. A French study published in 1987 found that oxerutins combined with compression stockings were significantly more helpful for leg ulcers than the stockings alone. 8 Other positive results have been reported as well. 9 However, some experiments found oxerutins to have no benefit in treating or preventing leg ulcers. 10 Until more research is done, the most we can say is that oxerutins mightbe helpful for leg ulcers—especially if combined with compression stockings.


Some evidence suggests that oxerutins might be helpful for hemorrhoids, as well. A double-blind study enrolling 97 pregnant women found oxerutins (1,000 mg daily) significantly better than placebo in reducing the pain, bleeding, and inflammation of hemorrhoids. 11


Women who have undergone surgery for breast cancer may experience a lasting and troublesome side effect: swelling in the arm caused by damage to the lymph system. Along with the veins, the lymph system is responsible for returning fluid to the heart, but when the system is damaged, fluid can accumulate. Three double-blind, placebo-controlled studies enrolling more than 100 people have examined the effectiveness of oxerutins in this condition. 12 In one trial, oxerutins worked significantly better than placebo at reducing swelling, discomfort, immobility, and other measures of lymphedema over a 6-month treatment period, with better results appearing each month 13 —suggesting that, for women with this condition, the full effect of oxerutins might take months to realize.

Two smaller studies also found oxerutins to be more effective than placebo, but the researchers were not sure that the improvement was large enough to make a real difference. 14 In all of these studies, the dosage used was 3 g daily—about 3 times the typical dosage for venous insufficiency.

Post-surgical Edema

Swelling often occurs in the recovery period following surgery . In one double-blind trial, researchers gave oxerutins or placebo for 5 days to 40 people recovering from minor surgery or other minor injuries, and they found oxerutins significantly helpful in reducing swelling and discomfort. 15


  1. Pulvertaft TB. General practice treatment of symptoms of venous insufficiency with oxerutins. Results of a 660 patient multicentre study in the UK. Vasa. 12(4):373-6.
  2. Unkauf M, Rehn D, Klinger J, de la Motte S, Grossmann K. Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings. Arzneimittelforschung. 46(5):478-82.
  3. MacLennan WJ, Wilson J, Rattenhuber V, Dikland WJ, Vanderdonckt J, Moriau M. Hydroxyethylrutosides in elderly patients with chronic venous insufficiency: its efficacy and tolerability. Gerontology. 40(1):45-52.
  4. Boisseau MR, Taccoen A, Garreau C, Vergnes C, Roudaut MF, Garreau-Gomez B. Fibrinolysis and hemorheology in chronic venous insufficiency: a double blind study of troxerutin efficiency. J Cardiovasc Surg (Torino). 36(4):369-74.
  5. Rehn D, Golden G, Nocker W, Diebschlag W, Lehmacher W. Comparison between the efficacy and tolerability of oxerutins and troxerutin in the treatment of patients with chronic venous insufficiency. Arzneimittelforschung. 43(10):1060-3.
  6. Bergstein NAM. Clinical study on the efficacy of O-(beta-Hydroxyethyl)Rutoside (HR) in varicosis of pregnancy. J Int Med Res. 1975;3:189-193.
  7. Sohn C, Jahnichen C, Bastert G. Effectiveness of beta-hydroxyethylrutoside in patients with varicose veins in pregnancy [in German]. Zentralbl Gynakol. 1995;117:190-197.
  8. Stegmann W, Hubner K, Deichmann B, et al. The efficacy of O-(beta-hydroxyethyl)-rutosides in the treatment of venous leg ulcers [in French]. Phlebologie. 1987;40:149-156.
  9. Wadworth AN, Faulds D. Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs. 44(6):1013-32.
  10. Wadworth AN, Faulds D. Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs. 44(6):1013-32.
  11. Wijayanegara H, Mose JC, Achmad L, Sobarna R, Permadi W. A clinical trial of hydroxyethylrutosides in the treatment of haemorrhoids of pregnancy. J Int Med Res. 20(1):54-60.
  12. Piller NB, Morgan RG, Casley-Smith JR. A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs. Br J Plast Surg. 41(1):20-7.
  13. Piller NB, Morgan RG, Casley-Smith JR. A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs. Br J Plast Surg. 41(1):20-7.
  14. Taylor HM, Rose KE, Twycross RG. A double-blind clinical trial of hydroxyethylrutosides in obstructive arm lymphoedema. Phlebologie. 1993;(suppl 1):22-28.
  15. Fassina A, Rubinacci A. Post-traumatic oedemas. A controlled study into the activity of hydroxyethylrutoside [translated from Italian]. Gazz Med Ital Arch Sci. 1987;146:103-109.


No one has made any comments yet. Be the first!

Your Comment