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Inconsistent evidence from small double-blind trials suggest that pantethine might lower blood levels of triglycerides and, to a lesser extent, cholesterol . 1 High triglycerides, like high cholesterol, increase risk of heart disease and strokes. Some people have only modestly elevated cholesterol but very high triglycerides, so pantethine may be especially useful for them.
Weak evidence hints that pantothenic acid might be helpful for rheumatoid arthritis . 2 Pantothenic acid is also recommended as an athletic performance enhancer , but there is no evidence at all that it works. It is also sometimes referred to as an anti-stress nutrient because it plays a role in the function of the adrenal glands, but whether it really helps the body withstand stress is not known.
- Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR. Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia. Atherosclerosis. 50(1):73-83.
- [No authors listed]. Calcium pantothenate in arthritic conditions. A report from the General Practitioner Research Group. Practitioner. 1980;224:208-211.