Pazopanib Side Effects and Warnings

What are the precautions when taking this medicine?

• If you have heart disease, talk with healthcare provider.

• If you have high blood pressure, talk with healthcare provider.

• If you have liver disease, talk with healthcare provider.

• If you are having surgery, talk with healthcare provider.

• If you have thyroid disease, talk with healthcare provider.

• If you have had an ulcer or bleeding from your stomach or intestines, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Talk with healthcare provider before receiving any vaccinations. Use with this medicine may either increase the risk of serious infection or make the vaccination less effective.

• Tell dentists, surgeons, and other healthcare providers that you use this medicine.

• You may bleed more easily. Be careful. Avoid injury. Use soft toothbrush, electric razor.

• Do not take St John's wort with this medicine. It may make this medicine less effective.

• Talk with healthcare provider before using other: aspirin, aspirin-containing products, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain medicines, or vitamin E.

• Avoid grapefruit and grapefruit juice.

• Use birth control that you can trust to prevent pregnancy while taking this medicine.

What are some possible side effects of this medicine?

• Anemia, low white blood cell count, and low platelet count.

• Feeling tired or weak.

• Headache.

• Diarrhea.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• High blood pressure.

• High blood sugar.

• Low blood sugar. Signs include anger, shaking, fast heartbeat, confusion, or sweating. Keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar.

• Belly pain.

• Change in color of hair.

• Liver damage can rarely occur.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.

• Chest pain.

• Difficulty breathing.

• Fast heartbeat.

• Severe dizziness or passing out.

• Change in strength on one side greater than the other, difficulty speaking or thinking, change in balance, or blurred vision.

• Skin wound that will not heal.

• Severe belly pain.

• Severe nausea or vomiting.

• Severe diarrhea.

• Black, tarry, or bloody stools.

• Feeling extremely tired or weak.

• Unusual bruising or bleeding.

• Dark urine or yellow skin or eyes.

• Not able to eat.

• Any rash.

• No improvement in condition or feeling worse.