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Note:Due to the presence of unlisted pharmaceuticals, PC-SPES should not be used.
It's no surprise that side effects of PC-SPES closely resemble those of estrogen when taken by men for the treatment of prostate cancer; 1 it may cause breast or nipple tenderness or swelling, loss of body hair, hot flashes, and loss of libido. Some individuals have also reported leg cramps, nausea and vomiting, and blood clots in the legs. 2 Side effects of PC-SPES increase with dosage.
There is one case report of PC-SPES taken at twice the recommended dose causing internal bleeding, presumably due to the presence of warfarin (Coumadin), a strong blood thinner. 3
- Moyad MA, Pienta KJ, Montie JE. Use of PC-SPES, a commercially available supplement for prostate cancer, in a patient with hormone-nave disease. Urology. 1999;54:319–324.
- Kameda H, et al. A phase II study of PC-SPES, an herbal compound, for the treatment of advanced prostate cancer (PCa) [abstract]. American Society of Clinical Oncology 35th Annual Meeting, Atlanta, Ga; 1999. Abstract 1230.
- Weinrobe MC, Montgomery B. Acquired bleeding diathesis in a patient taking PC-SPES [letter]. N Engl J Med. 2001;345:1213–1214.