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The rhizome (underground extension of the stalk) of picrorhiza has a long history of use in Indian Ayurvedic medicine for the treatment of digestive problems. Other traditional uses include treatment of scorpion sting, asthma, liver diseases, and febrile infections.
A typical recommended dose of powdered picrorhiza ranges from 400 mg to 1,500 mg daily, or an equivalent amount in extract form.
Like all plants, picrorhiza contains a variety of chemicals. Some of the more investigated of these constituents include picroside I, kutkoside, androsin, and apocynin. Some picrorhiza extracts are standardized to contain a stated amount of one or more of these substances. However, since no constituent of picrorhiza has any established medicinal benefit, such standardization has no known practical implication.