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The prickly ash tree has a long history of use in Native American medicine. The bark was used to treat intestinal cramps, dry mouth, muscle and joint pain, toothache, nervous disorders, arthritis, and leg ulcers. The berries were used for circulatory problems such as intermittent claudication and Raynaud’s syndrome .
Prickly ash is often taken in the form of tea, made by boiling 5–10 grams of the bark in a cup of water for 10–15 minutes. For toothache, the pieces of the bark may be chewed. Tinctures are also available.