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Prickly ash has not undergone any modern scientific safety evaluation. It contains potentially toxic alkaloids; whether or not these lead to any harmful effects remains unknown. 1 Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
- Bowen JM, Cole RJ, Bedell D, et al. Neuromuscular effects of toxins isolated from southern prickly ash ( Zanthoxylum clava-herculis ) bark. Am J Vet Res. 1996;57:1239–44.